DONALD WONG, PH.D. ASSOCIATE PROFESSOR COURSE DIRECTOR: NEUROSCIENCE & CLINICAL NEUROLOGY DEPARTMENTS:
Cornell University, Ithaca, NY, B.S. in Physics/Biophysics, 1973 Columbia University, College of P & S, NYC, Ph.D. in Anatomy, 1981 Washington University School of Medicine, Postdoc, 1981-84 Indiana University School of Medicine: since 1984
RESEARCH ACTIVITIES: A central interest of our research is to understand how the brain processes complex sounds in generating auditory perception. Extracellular single-unit recording is used to analyze the functional organization of the mammalian auditory cortex. Neuroanatomical tract-tracing is employed to determine the anatomical connections of physiologically-identified regions. A computational neuroscience approach is further used to model single neurons with artificial neural-networks and signal-processing techniques. A second area of research is directed at plasticity in the central auditory pathway. The auditory nerve of drug-deafened animals is electrically stimulated to mimic the clinical condition found in profoundly-deaf patients surgically implanted with cochlear prostheses. "Artificial" nerve stimulation in deafened animals will be evaluated for its potential to reverse nerve degeneration and induce functional reorganization. A third area will use positron-emission tomography (PET) to image the human cerebral cortex, and compare regions activated by speech in both normal-hearing and profoundly-deaf patients fitted with different prosthetic devices.
SELECTED PUBLICATIONS: Gandour, J., Wong, D. and Hutchins, D. (1998) Pitch Processing in the human brain is influenced by language experience. NeuroReport 9: 2115-2119 (June). PDF Wong, D., Miyamoto, R.T., Pisoni, D.B., Sehgal, M., Hutchins, G. (1999) PET imaging of cochlear-implant and normal-hearing subjects listening to speech and nonspeech stimuli. Hearing Res. 132:34-42. Palakal, M.J. and Wong, D. (1999) Cortical representation of spatio-temporal pattern of firing evoked by echolocation signals: Population encoding of target features in real time. J. Acoust. Soc. Am. 106 (1):479-490. Miyamoto, R.T., Wong, D., Pisoni, D.B., Hutchins, G.D., Sehgal, M., Fain, R. (1999) Positron emission tomography (PET) in cochlear implant and auditory brainstem implant (ABI) recipients. Am. J. Otol., 20:596-601. Gandour, J.T., Wong, D. Hsieh, L., Weinzapfel, B., and Hutchins, G. (2000) A crosslinguistic PET study of tone perception. J. Cognitive Neuroscience 12(1):207-222. PDF Hsieh, L., Gandour, J., Wong, D., and Hutchins, G. (2001) Functional circuits engaged in speech perception depend on language experience. Brain and Language 76 (3): 227-252. PDF Miyamoto, R.T. and Wong, D. (2001) Positron emission tomography in cochlear implant and auditory brainstem implant recipients. J. Communication Disorders 34 (6): 473-478 (Nov-Dec). Wong, D., Pisoni, D.B., Learn, J., Gandour, J., Miyamoto, R.T., and Hutchins, G.D. (2002) PET imaging of differential cortical activation to monaural speech and nonspeech stimuli. Hearing Research 166/1-2: 9-23 (April). Gandour, J., Wong, D., Dzemidzic, M., Lowe M., Satthamnuwong, N., Li, X., and Tong, Y. (2002) A crosslinguistic fMRI Study of the perception of spectral and temporal cues underlying phonological processing. J. Cognitive Neuroscience, 14:7, 1076-1087. PDF Gandour, J., Wong, D., Lowe, M., Dzemidzic, M., Satthamnuwong, N., Tong, Y., and Lurito, J. (2002) Neural circuitry underlying perception of duration depends on language experience. Brain and Language 83:268-290. PDF Gandour, J., Dzemidzic, M., Wong, D., Lowe, M., Tong, Y., Hsieh, L., Satthamnuwong, N., and Lurito, J. (2003) Temporal integration of speech prosody is shaped by language experience: An fMRI study. Brain and Language 84(3): 318-336. PDF Gandour, J., Wong, D., Dzemidzic, M., Lowe, M., Tong, Y., and Li, X. (2003) A Crosslinguistic fMRI study of perception of intonation and emotion in Chinese. Human Brain Mapping, 18:149-157 (online- February 12, 2003; print in June). PDF Wong, D. (2003) The auditory cortex of the little brown bat. Advances in the Study of Echolocation in Bats and Dolphins. Editors: J. Thomas, C. Moss, and M. Vater. Feature Extraction in the auditory cortex for echolocation, Chap. X-4, University of Chicago Press. Wong, D. and Chen K. (2003) Relationship between frequency and delay tuning in the FM bat, Myotis lucifugus. Advances in the Study of Echolocation in Bats and Dolphins. Editors: J. Thomas, C. Moss, and M. Vater. University of Chicago Press. Palakal, M. and Wong, D. (2003) A biologically plausible framework leading to auditory perception in FM bats. Advances in the Study of Echolocation in Bats and Dolphins. Editors: J. Thomas, C. Moss, and M. Vater. University of Chicago Press.
Wong, D. (1998) Symposium: Imaging the Auditory System, Stem to Stern. Guest presentation for the American Academy of Audiology, April 2, Los Angeles. Palakal, M.J. and Wong, D. (1998) Information Processing in the Auditory Cortex. Presentation at the Biological Sonar Conference, May 27-June 2, Carvoeiro, Portugal. Wong, D. Gandour, J., Hsieh, L., Hutchins, G. (1998) Pitch processing in a linguistic and non-linguistic context: A crosslinguistic PET study. 4th International Conference on Functional Mapping of the Human Brain, June 7-12, Montreal. Hsieh, L., Gandour, J., Wong, D., and Hutchins, G. (2000) Functional heterogeneity of inferior frontal gyrus is shaped by linguistic experience. Cognitive Neuroscience Society, 7th Annual Meeting, April 9-11, San Francisco. Hsieh, L., Gandour, J., Wong, D., and Hutchins, G. (2000) PET investigation of the perception of Chinese tones. 6th International Conference on Functional Mapping of the Human Brain, June 12-16, San Antonio. Miyamoto, R., Wong, D. and Pisoni, D.B. (2000) PET imaging in a prelingually deaf subject: changes in brain activation after device use. American Speech-Language-Hearing Association (ASHA), November 16-19, Washington, DC. Gandour, J. Wong, D., Dzemidzic, M., Lowe, M., Satthamnuwong, N., and Lurito, J. (2001) Functional specialization for phonological processing in the left inferior prefrontal cortex. Cognitive Neuroscience Society, 8th Annual Meeting, March 25-27, New York City. Poster Gandour, J., Dzemidzic, M., Wong, D., Lowe, M., Tong, Y., Hsieh, L., and Lurito, J. (2001) Differential neural circuitry underlies the perception of Chinese tone and intonation: an fMRI study. NeuroImage 13(6): S533. 7th International Conference on Functional Mapping of the Human Brain, June 10-14, Brighton, England. Poster Gandour, J., Wong, D., Dzemidzic, M., Lowe, M., Satthamnuwong, N., Tong, Y., Li, X., and Xu, Y. (2002) A crosslinguistic fMRI study of spectral and temporal cues underlying phonological processing. Cognitive Neuroscience Society, 9th Annual Meeting, April 14-16, San Francisco. Poster Wong, D., Gandour; J., Dzemidzic, M., Lowe, M., Tong, Y., Li, X., Xu, Y. (2002) Cortical processing of linguistically-relevant spectral and temporal cues: A crosslinguistic fMRI study. Program No. 279.8. 2002 Abstracts Viewer/Itinerary Planner. Washington DC: Society for Neuroscience. CD-ROM. Gandour, J., Xu, Y., Wong, D. Dzemidzic, M., Lowe, M., Li, X., Tong, Y. (2003) Is the left posterior prefrontal cortex specialized for overt segmentation or something else? 9th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 18-22, New York City. Poster Li, X., Gandour, J., Wong, D., Dzemidzic, M., Lowe, M.,J., Bian, W. (2003) Fractionating Mediational Processes Underlying Speech Segmentation. 9th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 18-22, New York City. Poster Gandour, J., Dzemidzic, M., Wong, D., Lowe, M. Xu, Y., Tong, Y., Li, X. (2003) Specialization of posterior prefrontal cortex: segmentation or something else? 15th International Congress of Phonetic Sciences, August 3-9, Barcelona, Spain. dowong@iupui.edu last update - 06/13/03 anatomy.iupui.edu
|