Sunday AM: Genetics of Osteoporosis (Chair: M. Econs)
Continental Room of the Sun Valley Inn
1. Introduction to skeletal genetics (M. Econs, Indiana University)
2. Genetics of osteoporosis. Utility of mouse models (R. Klein, Oregon Health Sciences Center)
3. Gene targeting approaches in mice: Assessing the roles of Lrp5 and Lrp6 in osteoblasts (B. Williams, Van Andel Institute)
4. Autosomal dominant high bone mass: The phenotype (R. Recker, Creighton Univ)
5. Turning genetic discoveries into new treatments: The WNT/Lrp5 system as a source of new drug targets for skeletal diseases (Peter Bodine, Wyeth-Ayerst)
Sunday AM Abstracts

Sunday PM: The RIB Award/Plenary Lecture
Continental Room of the Sun Valley Inn
Strain-related control of bone (re)modeling: objectives, mechanisms and failures (L. Lanyon, Univ of London)

Alice L. Jee Young Investigator Award Winners
1. Fluid flow induces an increase in cell strain and intracellular calcuim production in osteocytes (Amber Bonivtch, Southwest Research Institute)
2. Non-resorbing osteoclasts secrete anabolic factors activating bone formation both in vitro and in vivo (Kim Henriksen, Nordic Bioscience A/S)
3. Gymnastic loading and distal radius cross-sectional asymmetry (Jodi Dowthwaite, SUNY Upstate Medical University)
4. Dietary energy deficits leading to weight loss can induce loss of cancellous bone (Sibyl Swift, Texas A&M University)
5. A neuronal mechanism regulates modeling and remodeling during functional adaptation to cyclic fatigue loading (Susannah Sample, University of Wisconsin - Madison )
6. The role of multi-scale porosity on bone ingrowth to tissue engineered scaffolds (Amy Wagoner Johnson, University of Illinois at Urbana-Champaign)
7. IGF-I signaling and the skeletal response to mechanical load (Roger Long, University of California, San Francisco)
8. Morphological study of retinoic acid-induced malformation of skeletal tissues during axolotl limb regeneration (Bingbing Li, Indiana University-Purdue University Indianapolis)
9. A novel deletion in DMP1 is associated with a severe ARHR phenotype: a new contiguous gene syndrome? (Emily Farrow, Indiana University School of Medicine)
10. Ablation of the Galnt3 gene in mice leads to low circulating FGF23 concentrations and hyperphosphatemia despite increaded FGF23 gene expression (Shoji Ichikawa, Indiana University School of Medicine)
Sunday PM Abstracts

Ribs and other bones: A scientific interaction poster session (L. Yamamoto, Proctor & Gamble / S-A)
Limelight A room of the Sun Valley Inn (5 - 7:15pm, ribs and beer will be served)

Monday AM: Translational Research in OA – From Molecules to Animals to Humans (Chair: R. Loeser)
Continental Room of the Sun Valley Inn
1. Molecular mechanisms of cartilage destruction in osteoarthritis (R. Loeser, Wake Forest Univ)
2. Metabolism of chondrocytes in osteoarthritis: Why all this activity? (L. Sandell, Washington Univ)
3. Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage (M. Fosang, Melbourne Univ)
4. Mouse models and new therapeutic targets for OA (Qian Chen, Brown Univ)
5. Clinical research in OA – The NIH Osteoarthritis Initiative (G. Lester, NIAMS)
Monday AM Abstracts

Monday afternoon: NIH Workshop on Funding for Young Investigators(Representatives from NIAMS and NIDCR) (Chair: Gayle Lester)
Continental Room of the Sun Valley Inn
1. New investigator-oriented mechanisms
2. How to write a grant (G. Lester, NIAMS)

Monday PM: ASBMR/Harold M. Frost Award Presentations
Continental Room of the Sun Valley Inn
1. Trabecular structure analysis of the distal radius in adolescent patients with anorexia nervosa using ultra high resolution flat panel based Volume CT (Miriam Bredella, Massachusetts General Hospital, Dept. of Radiology )
2. Blocking VEGF as a potential approach to improve cartilage healing after OA (Tomoyuki Matsumoto, Children's Hospital of Pittsburgh)
3. FGF2 induced expression of the pyrophosphate generating enzyme, PC-1, is mediated by Runx2 and Msx2 (Nan Hatch, University of Michigan)
4. Unique roles of microRNA140 and its host gene WWP2 in cartilage biology (Yukio Nakamura, Childrens' Hospital & Harvard Medical School)
5. Role of Hypoxia Inducible Factor-1α Pathway in Bone Regeneration (Chao Wan, University of Alabama at Birmingham)
6. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation (Matthew Hilton, Washington University School of Medicine)
Monday PM Abstracts

Tuesday AM: Nanomechanics of Bone (Chair: E. Guo)
Continental Room of the Sun Valley Inn
1. What is nanomechanics of bone and why is it important? (E. Guo, Columbia Univ )
2. The post-yield behavior of bone: From nano to macroscopic length scales (X. Wang, Univ of Texas, San Antonio)
3. Fracture, fatigue and aging in bone dentin (R. Ritchie, Lawrence Berkeley Labs and Univ of California, Berkeley)
4. Effects of nanomechanical bone tissue properties on bone tissue strain: Implications for osteocyte mechanotransduction (D. Nicolella, Southwest Research Institute)
5. Strain–induced membrane deformation in osteocytes (S. Weinbaum, CCNY)
Tuesday AM Abstracts

Wednesday AM: Muscle Biology (Chair: K. Esser)
Continental Room of the Sun Valley Inn
1. Regenerative medicine based on muscle stem cells (J. Huard, Univ of Pittsburgh)
2. Mechanical regulation of growth signaling in skeletal muscle (K. Esser, Univ of Kentucky)
3. The molecular basis of skeletal muscle atrophy - parallels with osteoporotic signaling (S. Kandarian, Boston Univ)
4. Regulation of muscle size in humans: Role of myostatin? (M. Bamman, Univ of Alabama)
Wednesday AM Abstracts

Wednesday PM: Bone as an Endocrine Organ (Chair: B. Lecka-Czernik)
Continental Room of the Sun Valley Inn
1. Reciprocal regulation of bone and energy metabolisms (Na Kyung Lee, Columbia University)
2. Common regulatory pathways controlling energy metabolism and bone mass(C. Rosen, Jackson Labs)
3. Nutritional hormones and the entero-osseous axsis(C. Isales, Medical College of Georgia)
4. Local and systemic functions of bone fat and its contribution to the energy metabolism, the effect of diabetes and obesity on bone (B. Lecka-Czernik, Univ of Toledo)
Wednesday PM Abstracts