Education

• Ursinus College, Collegeville, PA, BS, Chemistry, 1973
• George Washington University, Washington, D.C., MS, Anatomic Pathology, 1975
• Medical College of Ohio, Toledo, OH, PhD, Medical sciences Anatomy, 1980
• Indiana University School of Medicine, Postdoctoral Fellowship, 1980-1983
• Visiting Scholar 1994-1995 Univ. of Michigan Medical School Department of Pathology

Academic Appointments

• Assistant Professor, Hershey Medical Center, Penn State University, 1983-1986
• Assistant through Full Professor, University of Kansas Medical Center 1986-2000
• Professor of Anatomy & Cell Biology, Indiana University, 2000-present

CV in PDF format

Our laboratory studies cellular and molecular pathogenesis of various renal diseases including polycystic kidney disease (PKD) and other chronic kidney diseases. For Polycystic Kidney Disease, the laboratory is studying: 1) the cellular and molecular basis for cyst formation and on disease progression, 2) the role of growth factors and oncogenes on the development and progression of PKD, 3) identifying misexpressed proteins and mRNAs associated with multiorgan aspects of this disease,  4) the role of extracellular matrix, interstitial fibrosis and vascular alterations in the pathogenesis of PKD renal demise and 5) new model systems for studying PKD. Other studies include kidney development, diabetic nephropathy, and glomerulosclerosis.

• Moe, S., N. Chen, M. Seifert, R. Sinders, D. Duan, X. Chen, Y. Liang, J.S.t Radcliff, K. White, V.H. Gattone. A Rat model of Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) and the Effect of dietary protein source. Kidney Intern 75(2):176-184, 2009.
• Muchatuta, M.N., V.H. Gattone, F.A. Witzmann, B.L. Blazer-Yost. Structural and Functional Analyses of Liver Cysts from the BALB/c-cpk Mouse Model of Polycystic Kidney Disease. Exp Biol Med (Maywood). 234(1):17-27, 2009.
• Gattone V. H., N. Chen, R. Sinders, M. Seifert, D. Duan., D. Martin, C. Henley, C., S.M.
  Moe. Calcimimetics inhibit late stage cystic growth in ADPKD. J Am Soc Nephrol,
  20(7):1527-1532, 2009.
• Gattone V. H., R.M.Sinders, T.A. Hornberger, A.G. Robling. Late progression of renal
  pathology and cyst enlargement is reduced by rapamycin in a mouse model of
  nephronophthisis.. Kidney Int 76(2):178-182, 2009.
• Moe, S.M., M.F. Seifert, N.X. Chen, R.M. Sinders, X. Chen, D. Duan, C. Henley, D. Martin,
  and V.H. Gattone. R-568 reduces ectopic calcification and improves bone histology in a rat
  model of chronic kidney disease-mineral bone disorder (CKD-MBD). Nephrol. Dialysis &
  Transpl. 24(8):2371-2377, 2009.
• Clendenon S.G., B. Shah, C.A. Miller, G. Schmeisse, A. Walter, V.H. Gattone, K.F. Barald,
  Q. Liu, and J.A. Marrs. Cadherin-11 controls otolith assembly: Evidence for extracellular
  cadherin activity. Dev Dyn. 238(8):1909-1922, 2009.
• Tammachote R., C.J. Hommerding, R.M. Sinders, C.A. Miller, P.G. Czarnecki, A.C.
  Leightner, J.L. Salisbury, C.J. Ward, V.E. Torres, V.H. Gattone, and P.C. Harris. Ciliary
  and centrosomal defects associated with mutation and depletion of the Meckel syndrome
  genes MKS1 and MKS3. Hum Mol Genet. 18(17):3311-3323, 2009.
• Lai X, B.L. Blazer-Yost, V.H. Gattone, M.N. Muchatuta, and F.A.Witzmann. Protein composition of liver cyst fluid from the BALB/c-cpk/+ mouse model of autosomal recessive polycystic kidney disease. Proteomics. 9(14):3775-3782, 2009.
• Clendenon SG, B. Shah, C.A. Miller, G. Schmeisser, A. Walter, V.H. Gattone, K.F. Barald , Q. Liu and J.A. Marrs. Cadherin-11 controls otolith assembly: evidence for extracellular cadherin activity. Dev Dyn. 238(8):1909-1922, 2009.
• LeBleu V., H. Sugimoto, T.M. Mundel, B. Gerami-Naini, E. Finan, C.A. Miller, V.H. Gattone, L. Lu , C.F. Shield, J. Folkman, and R. Kalluri. Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol. 20(11):2359-2370, 2009.
• Mason S.B., X. Lai, R.L. Bacallao, B.L. Blazer-Yost, V.H. Gattone, K.C. Wang, F.A. Witzmann. The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid. Proteomics – Clin. Appl. 3:1247-1250, 2009.
• Kubek D.J., V.H. Gattone and M.R. Allen. Methodological assessment of acid-etching for visualizing the osteocyte lacunar-canalicular networks using scanning electron microscopy. Microscopy Research and Technique 73(3):182-6, 2010.
• Mason S.B., Y.Liang, R.M. Sinders, C.A. Miller, T. Eggleston- Gulyas, R. Crisler-Roberts, P.C. Harris, V.H. Gattone. Disease stage characterization of hepatorenal fibrocystic pathology in the PCK rat model of ARPKD. Anat. Rec. 293(8):1279-1288, 2010.
• Torres V.E., A. Boletta, A. Chapman, V.H. Gattone, Y. Pei, Q. Qian, D.P. Wallace, T. Weimbs, R.P. Wüthrich. Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases. Clin J Am Soc Nephrol. 5(7):1312-1329, 2010.
• Mason S.B.,. Lai, H.N. Ringham, R.L. Bacallao, P.C. Harris, F.A. Witzmann, V.H. Gattone VH Differential Expression of Renal Proteins in a Rodent Model of Meckel Syndrome. Nephron Exp Nephrol. 117(2):e31-e38, 2010.