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Williams Jr., James C., PhD

Education

  • Rhodes College, BS, 1978
  • Cornell University, PhD, 1983
  • University of Alabama at Birmingham, Postdoctoral Fellowship, 1982-1986

 

Academic Appointments

  • 7/1/06-present Professor
  • 8/1/91-6/30/06 Associate Professor (tenured 7/1/98) Department of Anatomy & Cell Biology Indiana University School of Medicine
  • 1/1/87-7/31/91 Assistant Professor Department of Anatomy & Cell Biology Medical University of South Carolina (MUSC)
  • 7/1/86-12/31/86 Research Instructor Department of Physiology University of Alabama at Birmingham

 

CV in PDF format

Kidney stones affect a large number of Americans, with about 12% of 
people having at least one stone in their lifetime, and half of these 
people will have more than one stone. Stones are rarely 
life-threatening, but they cause intense pain and often require surgical 
procedures to be removed. The causes of kidney stones are not fully 
understood, but it is obvious that the causes are many, and thus the 
treatments for stones will also be diverse.

Our work is involved with two aspects of kidney stone diseases. The 
first is the study of human kidney stones using micro computed 
tomography (micro CT) and molecular spectroscopy to determine the 
compositions and structures of stones. Few stones are homogeneous in 
composition, and most show 'growth rings' that indicate the processes 
that occurred in the past to create the stone. Our laboratory was the 
first to apply micro CT to the study of stones, and we are discovering 
many new things about the nature of stones in different forms of kidney 
stone disease. Our work in this area is in close collaboration with 
surgeons who treat patients suffering from kidney stones.

We also study shock wave lithotripsy, one of the most used methods for 
treating kidney stones, but a method that is still poorly understood. 
That is, it is still not clear exactly how a shock wave breaks up a 
stone, nor how to make a better shock wave that will break up stones 
more effectively and injure tissue less. For this work we collaborate 
with a large team of investigators that includes physicians, engineers, 
and physicists.

  • Matlaga, B.R., J.A. McAteer, B.A. Connors, R.K. Handa, A.P. Evan, J.C. Williams, J.E. Lingeman, and L.R. Willis. The potential for cavitation-mediated tissue damage in shock wave lithotripsy. J Endourol 22(1):121-126, 2008.
  • Humphreys, M.R., N.L. Miller, J.C. Williams, A.P. Evan, L.C. Munch, and J.E. Lingeman. A new world revealed: early experience with digital ureteroscopy. J Urol 179:970-975, 2008. (made cover for journal issue)
  • Neucks, J.S., Y.A. Pishchalnikov, A.J. Zancanaro, J.N. VonDerHaar, J.C. Williams, and J.A. McAteer. Improved acoustic coupling for shock wave lithotripsy. Urol Res 36:61-66, 2008.
  • Evan, A.P, J.E. Lingeman, F.L. Coe, N.L. Miller, S.B. Bledsoe, A.J. Sommer, J.C. Williams, Y. Shao, and E.M. Worcester. Histopathology and surgical anatomy of patients with primary hyperparathyroidism and calcium phosphate stones. Kidney Int 74:223-229, 2008.
  • Evan, A.P., J.E. Lingeman, J.A. McAteer, and J.C. Williams, eds. Renal Stone Disease 2: Proceedings of the 2nd International Urolithiasis Research Symposium. American Institute of Physics, Melville, NY, 2008.
  • Pishchalnikov, Y.A., J.A. McAteer, R.J. VonDerHaar, I.V. Pishchalnikova, and J.C. Williams. The characteristics of broad and narrow focal zone lithotripters. In: Renal Stone Disease 2: Proceedings of the 2nd International Urolithiasis Research Symposium. A.P. Evan, J.E. Lingeman, J.A. McAteer, and J.C. Williams, eds. American Institute of Physics, Melville, NY, 2008, pp. 238-242.
  • McAteer, J.A., A.P. Evan, B.A. Connors, Y.A. Pishchalnikov, J.C. Williams, and J.E. Lingeman. Treatment protocols to reduce injury and improve stone breakage in SWL. In: Renal Stone Disease 2: Proceedings of the 2nd International Urolithiasis Research Symposium. A.P. Evan, J.E. Lingeman, J.A. McAteer, and J.C. Williams, eds. American Institute of Physics, Melville, NY, 2008, pp. 243-248.
  • Jackson, M.E., C.A. Beuschel, J.A. McAteer, and J.C. Williams. Morphology of major stone types, as shown by micro computed tomography (micro CT). In: Renal Stone Disease 2: Proceedings of the 2nd International Urolithiasis Research Symposium. A.P. Evan, J.E. Lingeman, J.A. McAteer, and J.C. Williams, eds. American Institute of Physics, Melville, NY, 2008, pp. 333-337.
  • Pishchalnikov, Y.A., J.A. McAteer, A.J. Zacanaro, J.S. Neucks, I.V. Pishchalnikova, and J.C. Williams. Effect of the test basket on lithotripter shock waves, cavitation field, and stone breakage. In: Renal Stone Disease 2: Proceedings of the 2nd International Urolithiasis Research Symposium. A.P. Evan, J.E. Lingeman, J.A. McAteer, and J.C. Williams, eds. American Institute of Physics, Melville, NY, 2008, pp. 342-347.
  • Pramanik, R., J.R. Asplin, M.E. Jackson, and J.C. Williams. Protein content of human apatite and brushite kidney stones: significant correlation with morphologic measures. Urol Res 36:251–258, 2008. [DK059933, NIHMS217886]
  • Pishchalnikov, Y.A., J.A. McAteer, and J.C. Williams. Effect of firing rate on the performance of shock wave lithotripters. BJU International 102:1681-1686, 2008. [PMC2588648]
  • McAteer, J.A., A.P. Evan, J.C. Williams, and J.E. Lingeman. Treatment protocols to reduce renal injury during shock wave lithotripsy. Current Opinion in Urology 19:192– 195, 2009.
  • Assimos, D.G., B. Chew, M. Hatch, R. Hautmann, R. Holmes, J.C. Williams, and J.S. Wolf. Evaluation of the stone former. In: J. Denstedt and S. Khoury, eds. Stone Disease. Second International Consultation on Stone Disease. Health Publications Editions21, Paris, 2008.
  • Pishchalnikov, Y.A., J.A. McAteer, I.V. Pishchalnikova, J.C. Williams, M.R. Bailey, and O.A. Sapozhnikov. Bubble proliferation in shock wave lithotripsy occurs during inertial collapse. Proceedings of the 18th International Symposium on Non-linear Acoustics, held in Stockholm, July, 2008. AIP Conf Proc 1022:460-463, 2008.
  • Miller, N.L., D.L. Gillen, J.C. Williams, A.P. Evan, S.B. Bledsoe, F.L. Coe, E.M. Worcester, B.R. Matlaga, L.C. Munch, and J.E. Lingeman. A formal test of the hypothesis that idiopathic calcium oxalate stones grow on Randall's plaque. BJU International 103:966-971, 2009.
  • Tanner, G.A., C. Rippe, Y. Shao, A.P. Evan, and J.C. Williams. Glomerular permeability to macromolecules in the Necturus kidney. Am J Physiol Renal 296:F1269-F1278, 2009. [PMID19339627]
  • Evan, A.P., J.E. Lingeman, F.L. Coe, S.B. Bledsoe, A.J. Sommer, J.C. Williams, A.E. Krambeck, and E.M. Worcester. Intra-tubular deposits, urine and stone composition are divergent in patients with ileostomy. Kidney Int 76:1081-1088, 2009.
  • Miller, N.L., J.C. Williams, A.P. Evan, S.B. Bledsoe, F.L. Coe, E.M. Worcester, L.C. Munch, S.E. Handa, and J.E. Lingeman. In idiopathic calcium oxalate stone formers, unattached stones show evidence of having originated as attached stones on Randall's plaque. BJU International, 105(2):242-245, 2010. [R01DK59933] [PMC2807918]
  • Evan, A.P., J.E. Lingeman, E.M. Worcester, S.B. Bledsoe, A.J. Sommer, J.C. Williams, A.E. Krambeck, C.L. Philips, and F.L. Coe. Renal histopathology and crystal deposits in patients with small bowel resection and calcium oxalate stone disease. Kidney International 78:310-317, 2010.
  • Krambeck, A.E., N.F. Khan, M.E. Jackson, J.E. Lingeman, J.A. McAteer and J. C. Williams. Inaccurate reporting of mineral composition by commercial stone analysis laboratories: implications for infection and metabolic stones. J Urol 184:1543-1549, 2010. [R01DK59933]
  • Daudon, M., O. Traxer, J.C. Williams, and D. Bazin. Randall's plaques. In: N. Rao, J. Kavanagh, and G.M. Preminger (eds) Urinary Tract Stone Disease, Springer, New York, in press.
  • Krambeck, A.E., J.E. Lingeman, J.A. McAteer and J. C. Williams. Analysis of Mixed Stones Is Prone to Error: A Study with U.S. Laboratories using Micro CT for Verification of Sample Content. Urol Res, in press. [R01DK59933]
  • Williams, J.C., J.A. McAteer, A.P. Evan and J.E. Lingeman. Micro-computed tomography (micro CT) for analysis of urinary calculi. Urol Res, in press. [R01DK59933]