St. Mary's College of Maryland; BA Anthropology, 1992

George Washington University; MA Anthropology, 1995

University of Missouri-Columbia; Ph.D. Biological Anthropology, 1998

Indiana University School of Medicine; Postdoctoral Fellow, 1999-2001

RESEARCH ACTIVITIES:

    Long-term research goals include understanding the effects of mechanical loading on bone at the organ, tissue, and cellular level. Specific interests include determinants of bone cell mechanosensitivity; research in this field involves studies of genetic regulation of mechanosensitivity, and cellular mechanisms involved in bone cell desensitization after mechanical loading.

SELECTED PUBLICATIONS:

Robling AG, Burr DB, Turner CH (2000) Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading. Journal of Bone Mineral Research 8:1596-1602.

Robling AG, Burr DB, Turner CH (2001) Skeletal loading in animals. Journal of Musculoskeletal and Neuronal Interactions 1:249-262.

Robling AG, Duijvelaar KM, Geevers JV, Ohashi N, Turner CH (2001) Modulation of longitudinal and appositional bone growth in the rat ulna by applied mechanical force. Bone 29:105-113.

Robling AG, Burr DB, Turner CH (2001) Recovery periods restore mechanosensitivity to dynamically loaded bone. J Exp Biol 204:3389-3399.

Robling AG, Hinant FM, Burr DB, Turner CH (2002) Shorter, more frequent exercise sessions enhance bone mass. Med Sci Sports Exer 34:196-202.

Robling AG, Hinant FM, Burr DB, Turner CH (2002) Improved bone structure and strength after long term mechanical loading is greatest if the loading is separated into short bouts. J Bone Miner Res 17:1545-54.

Robling AG, Li J, Shultz KL, Beamer WG, Turner CH (2002) Evidence for a skeletal mechanosensitivity gene on mouse Chromosome 4. FASEB J 10.1096/fj.02-0393fje.

Robling AG, Turner CH (2002) Mechanotransduction in bone: genetic effects on mechanosensitivity in mice. Bone 32:562-9.

Turner CH, Robling AG (2003) Designing exercise regimens to increase bone strength. Exerc Sport Sci Rev 31:45-50.

Robling AG, Li J, Shultz KL, Beamer WG, Turner CH (2003) Evidence for a skeletal mechanosensitivity gene on mouse Chromosome 4. FASEB J 17:324-6; 10.1096/fj.02-0561fje.

Daly RM, Saxon LK, Turner CH, Robling AG, Bass SL (2004) The relationship between muscle size and bone geometry during growth and in response to exercise. Bone 34:281-7.

Turner CH, Robling AG (2004) Exercise as an anabolic stimulus for bone. Curr Pharm Des 10:2629-41.

Schriefer JL, Robling AG, Warden SJ, Fournier AJ, Mason JJ, Turner CH (2005) A comparison of mechanical properties derived from multiple skeletal sites in mice. J Biomech 38:467-75.

Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robling AG, Harris SE (2005) Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J Biol Chem 280:20680-90.

Warden SJ, Robling AG, Sanders MS, Bliziotes MM, Turner CH (2005) Inhibition of the serotonin transporter (5-HTT) reduces bone accrual during growth. Endocrinol 146:685-93.

Schriefer JL, Warden SJ, Saxon LK, Robling AG, Turner CH (2005) Cellular accommodation and the response of bone to mechanical loading. J Biomech38:1838-45.

Alam I, Warden SJ, Robling AG and Turner CH (2005) Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene. J Bone Miner Res  20:438-46.

Saxon LK, Robling AG, Alam I, Turner CH (2005) Mechanosensitivity of the rat skeleton decreases after a long period of loading, but is improved with time off. Bone 36: 454-464.

Turner CH, Robling AG (2005) Exercises for improving bone strength. Br J Sports Med 39:188-9.

Turner CH, Robling AG (2005) Mechanisms by which exercise improves bone strength.
J Bone Miner Metab 23 (Suppl):16-22.

Alam I, Robling AG, Weissing S, Carr LG, Lumeng L, Turner CH. (2005) Bone mass and strength: phenotypic and genetic relationship to alcohol preference in P/NP and HAD/LAD rats. Alcohol Clin Exp Res 29:1769-76.

Charoonpatrapong K, Shah R, Robling AG, Alvarez M, Clapp DW, Chen S, Kopp RP, Pavalko FM, Yu J, Bidwell JP. (2006) HMGB1 expression and release by bone cells. J Cell Physiol 207:480-490.

BOOK CHAPTERS

Robling AG, Stout SD (2000) Histomorphometry of human cortical bone: applications to age estimation. In Katzenberg A, Saunders S (eds.): Biological Anthropology of the Human Skeleton. New York: Wiley-Liss, Inc. pp. 187-213.

Robling AG, Stout SD (2004) Histomorphology, geometry, and mechanical loading in past populations. In Agarwal SC, Stout SD (eds.): Bone Loss and Osteoporosis: an Anthropological Perspective. New York: Plenum Publishers, Inc. pp.185-201.

CURRENT FUNDING:

Agency: National Institutes of Health (K01 AR47879-01)
Title: Cytoskeletal modulation of bone cell mechanosensitivity.
Duration: 4/1/2002 – 3/31/2007
Role: Principal Investigator

Agency: National Institutes of Health (R01 AR053237-01)
Title: Lrp5 signaling in bone mechano-responsiveness.
Duration: 9/30/2005 – 9/29/2010
Role: Principal Investigator