University of Colorado, Boulder (Ph.D. in Anthropology) 1977

University of Kansas, Instructor in Anatomy, 1977-78; Assistant Professor of Anatomy, 1978-80

West Virginia University, Assistant Professor of Anatomy and Orthopedic Surgery, 1980-83; Associate Professor, 1983-1986; Professor, 1986-1990

Indiana University School of Medicine: Professor and Chair, since 1990

   Dr. Burr’s current research activities include evaluation of the effects of pharmacologic agents used to treat osteoporosis on properties associated with quality of the bone matrix, specifically, the accumulation and repair of microdamage, changes in mineralization and alterations to the collagenous matrix. He is also involved in studying the role that bisphosphonates play in vivo on osteocyte apoptosis, and the direct effects of bisphosphonates on the activity of individual osteoblasts. Related to this, he is performing studies to define the periods for primary and secondary mineralization of bone and how rates of mineralization are affected by anti-remodeling treatments. He has for many years been a leader in studying the role of skeletal fatigue and microdamage-mediated remodeling in bone biomechanical and physiological adaptation.

2003 A model for mechanotransduction in bone cells: The load bearing mechanosomes, Pavalko FM, Norvell SM, Burr DB, Turner CH, Duncan RL and Bidwell JP J Cell Biochem 88:104-112.

2003 Characterization of dynamic three-dimensional strain fields in the canine radius. Coleman JC, Hart RT, Owan I, Tankano Y [sic], and Burr DB J Biomech 35:1677-1683.

2003 Effects of broad frequency vibration on cultured osteoblasts. Tanaka SM, Li J, Duncan RL, Yokota H, Burr DB and Turner CH J Bioomech 36:73-80.

2003 Parathyroid hormone enhances mechanially induced bone formation, possibly involving L-type voltage-sensitive calcium channels. Li J, Duncan RL, Burr DB, Gattone VH, and Turner CH Endocrinol 144226-1233.

2003 Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH(1-34) for 18 months. Paschalis EP, Burr DB, Mendelsohn R, Hock JM and Boskey AL J Bone Miner Res 18:769-775.

2003 Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates. Ding M, Day JS, Burr DB, Mashiba T, Hirano T, Weinans H, Sumner DR, and Hvid I. Calcif Tiss Int 72:737-744.

2003 Biomechanics of Bone. Burr DB and Turner CH. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 5 th ed. Washington DC: ASBMR, Chapter 8.

2003 Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis? Burr DB and Radin EL. Rheum Dis Clin N Amer 29:675-685.

2003 Effects of physical training on proprioception in older women. Thompson KR, Mikesky AE, Bahamonde RE and Burr DB. J Musculoskel Neuron Interact 3:223-231.

2003 Microdamage and bone strength. Burr DB. Osteoporos Int 14 (Suppl 5):S67-S72.

2003 Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. Day JS, Ding M, Bednarz P, van der Linden JC, Mashiba T, Hirano T, Johnston CC, Burr DB, Hvid I, Sumner DR, and Weinans, H. J Orthop Res Online 11/6/2003

2003 Reconstructed bone end loads on the canine forelimb during gait. Coleman JC, Hart RT and Burr DB. J Biomech 36:1837-1844.

2003 Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs. Burr DB, Miller L, Grynpas, M, Li, J, Boyde A, Mashiba T, Hirano T, and Johnston CC. Bone 33:960-969.

2004 Anatomy and physiology of the mineralized tissues: Role in the pathogenesis of osteoarthrosis. Burr DB. Osteoarthritis and Cartilage 12:S20-S30.

2004 The importance of subchondral bone in the progression of osteoarthritis. Burr DB. J Rheumatol. Suppl 70:77-80.

2004 A comparison of bone strain measurements at anatomically sites using surface gauges versus strain gauged bone staples. Milgrom C, Finestone A, Hamel A, Mandes V, Burr D and Sharkey N. J Biomech 37:947-952.

2004 Bone quality: Understanding what matter. Burr DB. J Musculoskel Neuron Interact 4:184-186.

2004 The effect of prophylactic treatment with risedronate on stress fracture incidence among infantry recruits. Burr DB. Bone 35:418-424.

2004 Periosteum: biology, regulation, and response to osteoporosis therapies. Allen MR, Hock JM and Burr DB. Bone 35:1003-1012.

2005 Does early PTH treatment compromise bone strength? The balance between remodeling, porosity, bone mineral, and bone size. Burr DB. Curr Osteop Reports 3:19-24.

2005 Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone. Allen MR and Burr DB. Bone 36:311-316.

2005 Microdamage accumulation in the monkey vertebra does not occur when bone turnover is suppressed by 50% or less with estrogen or raloxifene. Li J, Sato M, Jerome C, Turner CH, Fan Z and Burr DB. J Bone Miner Metab 23 [suppl]:48-54.

2005 Osteoblast responses one hour after load-induced fluid flow in a three-dimensional porous matrix. Tanaka SM, Sun, HB, Roeder RK, Burr DB, Turner CH and Yokota, H. Calcif Tiss Int 76:261-271.

2005 Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. Warden SJ, Hurst JA, Sanders MS, Turner CH, Burr DB and Li J. J Bone Miner Res 20:809-816.

2005 Bone remodeling at the iliac crest can predict the changes in remodeling dynamics, microdamage accumulation, and mechanical properties in the lumbar vertebrae of dogs. Mashiba T, Hui S, Turner CH, Mori S, Johnston CC Jr, and Burr DB. Calcif Tiss Int 77:180-185.

2005 Imaging bone microdamage in vivo with positron emission tomography. Li J, Miller MA, Hutchins GD and Burr DB. Bone 37:819-824.

2006 Age-related change in the damage morphology of human cortical bone and its role in bone fragility. Diab T, Condon KW, Burr DB, and Vashishth D. Bone (in press)

BOOKS

Structure, Function, and Adaptation of Compact Bone. R.B. Martin and D.B. Burr. NY: Raven Press, 1989.

Skeletal Tissue Mechanics. R.B. Martin, D.B. Burr, and N. Sharkey. New York: Springer-Verlag, 1998.

Musculoskeletal Fatigue and Stress Fractures. D.B. Burr and C. Milgrom (eds). Boca Raton: CRC Press, 2001.

Bridging the Gap Between Dental and Orthopaedic Implants. L. Garetto, C.H. Turner, R.L. Duncan and D.B. Burr (eds). Indianapolis, IN: Indiana Unviersity School of Dentistry, 2002.

CURRENT FUNDING

1996-2007 : "Musculoskeletal Training Program," Program Director, NIH, 5-1-96 to 4-30-07.

2004-2005 : “Sun Valley Skeletal Tissue Workshop,” Principal Investigator, Orthopaedic Research and Education Foundation (OREF), 7-01-05 to 6-30-06.

2002-2007 : “Remodeling Suppression: Damage Accumulation and Bone Toughness,” Principal Investigator, NIH, 7-1-02 to 6-30- 07.

2002-2007 : “Dose Response Effects of Risedronate and Alendronate on Bone Remodeling and Microdamage Accumulation in Dogs,” Principal Investigator, Procter and Gamble Pharmaceuticals..

2002-2007 : “Raloxifene Research Project: Comparative Analysis of Raloxifene to Alendronate and Risedronate in the Dog Skeleton,” Principal Investigator, Eli Lilly and Co.

2003-2006 : “Bone Effects of Subcutaneous Teriparatide Following Discontinuation of Alendronate Treatment in Postmenopausal Women with Osteoporosis,” Principal Investigator, Eli Lilly and Co.

2003-2006 : “Dose Response Effects of Risedronate and Alendronate on Osteocyte Apoptosis and Bone Remodeling,” Principal Investigator, Procter and Gamble Pharmaceuticals.

2004-2006 : “The Effects of Alendronate and Risedronate Withdrawal on Bone in Ovariectomized Rats,” Principal Investigator, Procter and Gamble.

2005-2006 : “Effects of Strontium With and Without Calcium on Prevention of Bone Loss and on Bone Material Properties in Ovariectomized Rats,” Procter and Gamble.

2005-2006 : “Effects of OPG and Bisphosphonates on Bone Formation”, Amgen.

2006- : “Fatigue Life of Bone Following Treatment with Anti-Resorptive Agents”, Eli Lilly and Co.