Case Western Reserve University, Physical Chemistry Ph.D., 1983

Columbia University/Marine Biological Laboratory Postdoctoral Associate, 1983-1984

Howard Hughes Medical Institute/Woods Hole Oceanographic Institution, Research Associate, 1984-1988

Mayo Clinic, Research Associate, 1988-1990

University of Massachusetts Medical Center, Postdoctoral Associate, 1990-1993

Indiana Schools of Medicine and Dentistry: since 1993

RESEARCH ACTIVITIES:

Ten million people in the US suffer from osteoporosis, a disease of reduced bone mass and debilitating fractures. Another 30-40 million in this country are at risk for this disease. Parathyroid hormone (PTH) is currently the only FDA-approved drug for osteoporosis that induces new bone growth, however, the molecular mechanisms responsible for this anabolic effect are not understood.

SELECTED PUBLICATIONS:

Feister HA, Onyia JE, Miles RR, Yang X, Galvin R, Hock JM, and Bidwell JP (2000) The expression of the nuclear matrix proteins NuMA, topoisomerase II-a, and -b in bone and osseous cell culture: regulation by parathyroid hormone. Bone 26: 227-234.

Feister HA, Torrungruang K, Thunyakitpisal P, Parker GE, Rhodes SJ, and Bidwell JP (2000)The NP/NMP4 transcription factors have distinct osteoblast nuclear matrix subdomains. J Cell Biochem :79(3): 506-517.

Thunyakitpisal P, Alvarez M, Tokunaga K, Onyia JE, Hock J, Ohashi N, Feister H, Rhodes, SJ, Bidwell JP (2001) Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts. J Bone & Mineral Res 16: 10-23.

Alvarez MB, Thunyakitpisal P, Rhodes SJ, Everett ET, Bidwell JP (2001) Assignment of Nmp4 to mouse chromosome 6 band F1 flanked by D6Mit134 and D6Mit255 using radiation hybrid mapping and fluorescence in situ hybridization. Cytogenetics and Cell Genetics. 94: 3-4: 244-245.

Bidwell JP, Torrungruang K, Alvarez M, Rhodes SJ, Shah R, Jones DR, Charoonpatrapong K, Hock JM, Watt AJ (2001) Involvement of the nuclear matrix in the control of skeletal genes: the NMP1 (YY1), NMP2 (Cbfa1), and NMP4 (Nmp4/CIZ) transcription factors. Critical Reviews in Eukaryotic Gene Expression 11(4):279-97

Torrungruang K, Shah R, Alvarez M, Bowen DK, Gerard R, Pavalko FM, Elmendorf JS, Charoonpatrapong K, Hock J, Rhodes SJ, Bidwell JP (2002) Osteoblast intracellular localization of Nmp4 proteins. Bone 30(6):931-6.

Torrungruang K, Alvarez M, Shah R, Onyia JE, Rhodes SJ, Bidwell JP (2002) DNA binding and gene activation properties of the Nmp4 nuclear matrix transcription factors. J Biol Chem. 277: 16153-16159.

Pavalko FM, Norvell SM, Burr DB, Turner CH, Duncan RL, Bidwell JP (2003) A Model for mechanotransduction in bone cells: The load-bearing mechanosomes. J Cell Biochem. 88: 104-112.

Alvarez M, Rhodes SJ, Bidwell JP 2003 Context-dependent transcription: all politics is local. Gene 313: 43-57

Shah R, Alvarez M, Jones DR, Torrungruang K, Watt AJ, Selvamurugan N, Partridge NC, Quinn CO, Pavalko FM, Rhodes SJ, Bidwell JP 2004 Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts. Am J Physiol Endocrinol Metab. 287: E289-E296.

Norvell SM, Alvarez M, Bidwell JP, Pavalko FM 2004 Fluid shear stress induces beta-catenin signaling in osteoblasts. Calcif Tissue Int. 75: 396-404.

Guyl JC, Hunter CS, Showalter AD III, Smith TPL II, Charoonpatrapong K, Sloop KW, Bidwell JP, Rhodes SJ 2004 Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein Gene 336: 263-273.

Alvarez M, Shah R, Rhodes SJ, Bidwell JP 2005 Two promoters control the mouse Nmp4/CIZ transcription factor gene. Gene. 347(1): 43-54.

Charoonpatrapong K, Shah R, Robling AG, Alvarez M, Clapp DW, Chen S, Kopp RP, Pavalko FM, Yu J, Bidwell JP 2006 HMGB1 expression and release by bone cells. Journal of Cellular Physiology. 207: 480-490.

BOOK CHAPTERS

Bidwell JP and Spotte S 1985 Artificial Seawaters: formulas and methods. Jones and Bartlett Publishing Company, Boston, 349pp.

Lian JB, Stein GS, Owen TA, Bortell R, Bidwell JP, Breen E 1991 Vitamin D regulation of the bone specific osteocalcin gene is functionally related to osteoblast growth and differentiation. pp12-20. In: AW Norman, R Bouillon and M Thomasset (eds.)

Vitamin D. Gene regulation, structure-function analysis and clinical application. Proceedings of the eighth workshop on vitamin D. Paris France July 5-10, 1991. Walter de Gruyter Berlin New York.

Lian JB, Stein GS, Owen TA, Tassinari MS, Aronow M, Collart D, Shalhoub V, Perua S, Dworetzky S, Bidwell JP, Pockwinse S 1992 Gene expression during development of the osteoblast phenotype: an integrated relationship of cell growth to differentiation. pp 165-222. In: GS Stein and JB Lian (eds.) Molecular and celluar approaches to the control of proliferation and differentiation. Academic Press, Inc., San Diego.

Lian JB, Stein GS, Owen TA, Bortell R, Shalhoub V, Bidwell JP, Breen E, Barone LM, van Wijnen AJ, Aronow M 1992 Regulation of osteocalcin gene expression during growth and differentiation of the bone cell phenotype. pp159-179. In: Z. Davidovitch (ed.) The biological mechanism of tooth movement and craniofacial adaptation. EBSCO Media, Birmingham, Alabama.

Stein GS, Lian JB, Owen TA, Bidwell JP, Shalhoub V, Breen E, van Wijnen AJ and Stein JL 1992 Contributions of cell structure to integrated expression of cell growth in tissue-specific genes during osteoblast differentiation. pp277-286. In: H Slavkin and P Price (eds.) Chemistry and biology of mineralized tissues. Elsevier, Amsterdam, the Netherlands.

CURRENT FUNDING

NIH Grants:
Agency: NIH 2 R01 DK053796
Title: Nmp4/CIZ regulation of bone phenotype
Date: 08/01/2006-07/31/2010
Role on grant: PI